1200 horse parts breakage
 

I'm trying to put my '97 Dodge 2500 CCLB together with all heavy duty parts including the drivetrain, Dana 80 chromemoly axles, 37 spline TruTrac, largest yokes and driveshafts I could get made, 271 TC, Firepunk stage 2, D&J CR short block, Hamilton street head w/ retainers,165# springs, extreme pushrods, 13mm Farrell pump and a 64/80 compounds.
So will parts breakage be front to back anyway or will it be head gaskets and converter, transmission issues? My truck will be used for drag racing and some sled pulling.

From what I read on here, pulling truck have drive line issues.
Drag trucks have motor and Trans problems.

At that power level anything can happen. Off your list sounds like you are doing what you can to keep it together... just not sure why you are using common rail pistons

Maybe a 24v head? Hamilton isn't making a 24v yet, are they?

I was told that the 12v block would break within a year at the 2200 ft pounds of torque I will be making and the CR block was better. The head is a 12V street head with a 1.850 intake and 1.750 exhaust.

So then are the injector spray angles going to be modified for the center bowl, CR pistons? I have no clue if that's even possible.

Will a 12v head even work on a CR block?

I know Infinite Performance can do a custom spray angle for a 12v 6.7L . OP, sounds like a beast, keep us updated.

It's possible, knowing what angle to use with what bowl/dome design is the more important factor.

The most frugal man doing a project ends up spending the most money in the end, typically.

Truth!
OP doesn't matter what block you use at 1200hp you are on borrowed time with a factory cast block. Best thing is keep the torque down. At 900hp I split a 5.9 CR block, made 907 on a 53 VP44 block no issues, and had a service truck blow the bottom end out stock

What other block options are out there besides high dollar aluminum ones?

Filled and deckplated

I'm hoping the 64/80 compounds will keep the horsepower down some and I won't be using nitrous for sure now.

Compounds will just raise the torque which will shorten the lifespan drastically. You want the least amount of torque to get a factory block to live.

What were the reasons for going with a cr block instead of an international 12v block?

You can also sleeve down a 6.7 block. This is the route I have to go. I doubt we make enough power with a single turbo to hurt it.

I'm going by what Drew at D&J told my mechanic. If I have to sell the compounds then I will. I sure don't want to break the motor starting off.

If it's a standard S480 then that will be the hp limiting factor of your setup. With a 12v you are pretty much limited to around 900hp with an S480. Local guy here has a nice 97 built by Scheid with a S480 as his primary and I believe a 362 as the secondary. He has dynoed out at around 900hp on many occasions. And he has about 30k street miles on that motor built by Scheid and no block issues to speak of. He also runs nitrous at the the track sometimes as well. The head is Fire ringed with 14mm head studs.

I would trust D&J on the motor build and keep the turbo's you have. I seriously doubt you have enough air to hurt that motor so long as egts are kept in check.