Personally I consider big to be around double the stock HP, but when talking about this lift pump stuff and the overall potential and efficiency of the motor, I couldn't tell you. It would be as simple as using an equasion and the dimensions of the motor to figure out how much power it can possibly produce, and then you would know how much air, and fuel it needs. Its possible that the engine itself would not be strong enough to be making that much power though.
So does the stock lift pump have enough throw to run safely with the hamilton cam? I think dual lift pumps would work well. Doubling the amount of fuel, and have them phased opposite so that the fuel pressure does not ocilate.
I believe all of Hamilton's cams have a longer stroke for the stock lift pump. I have also heard that the stock lift pump is capable of supporting 600ish HP.
I recommend reading a lot before asking to many questions. Most people making "big" HP are running either belt driven mechanical lift pumps or bigger electric lift pumps. What do you consider "big" HP though?
If anyone wants Cummins filter heads with fleet guard filters, 1/2 line and fittings let me know, I won't be using mine. It was all setup for the belt pump. Also have enlarged fitting for the injection pump, no big neck down like -AN fittings.