overdrive unlock for 6.7's is $299
unlock for the 06/07 5.9's is $99
If the truck is '07-09, you can use the XRT Pro to tune the TCM in "transmission only" mode and can stack it with stock or aftermarket engine tuning.
If the truck is 10-12, the trans only mode only works with stock tuning
But yes, the XRT Pro supports the overdrive software
hth