Almost all of the time, Garrett uses Ti wheels on the secondary in a compound setup due to the air charge temperature. I can't recall off the top of my head, but the aluminum wheel long-term service temperature is lower than you would think for commercial apps...like around 300F. Cast/ductile iron covers are needed for containment...the heavier wheel, if it ever let go (say due to a casting defect) would pulverize a cast Al cover.
Ti wheels are also used where corrosion by salt (marine) has caused issues with Al wheels.
As for the weight, yes they are heavier, but remember the turbine is an an overwhelming % of the total rotor mass. And you see in many cases for commercial vehicles where the turbine seems rather large (to us in the hi-po world), the compressor weight is just not a big deal.
Titanium's coefficient of thermal expansion is very low....which is fantastic because the housing is always going to grow more than the wheel....so as you flog it...the clearance goes up, which is generally OK for commercial vehicles.
And yes the fatigue life is 6X or more of the same aluminum alloy wheel.