Lower timing also moves the power down towards lower RPM. For towing, you don't need power at 2500RPM, you need it from 1500-up. Lower timing will help that.
Chris
I picked up a nice mpg gain on my old work truck 12v going to around 21* timing. It had 4.10 gears and was always around 2200 rpm plus going down the road.
Big drop in egt's also when towing heavy, all around a better truck than it was at 16*