I would like to suggest using a pulse adapter and a timing light
Sanp-on pulse adapter. I am running .093 SS lines and a 180 HP pump. I set my plunger lift to 5.9mm (21 deg) and it is actually running at 15.8 deg according to the timing light (I had to make a TDC indicator on the balancer). With that being said I will go through my set up.
I am running a Schied street cam, SO pistons DDP250 injectors (never checked Pop pressure), 181 DV's, a flat fuel plate about 3/4 of the way back, heavy AFC spring, 3K gov springs, Steed speed billet manifold with T-4 flange and Turbonetics billet 64mm t-series and a midframe 88mm compounds. I live at 5300 ft and get 15.9 MPG around town and 19.7 MPG at 75-80 MPH and if I keep it at 70 MPH I have pulled off 22.3 MPG. There is very little smoke at any throttle position...at sea level it has a very light haze a wide open throttle...virtually no smoke.
I tried running stock injectors out of curiosity and they would make the same boost (set at 45-50psi) but ran like crap. They ran hot, very smoky, and horribly underpowered. I was able to pull off nearly the same fuel mileage. My truck is an 01 QCLB 4x4 6-spd with stock size tires and 3.55 gears.